The Cherokee Nation - largest of the Five Civilized Tribes of the Southeast - is a people of Iroquoian lineage. The Cherokee, who called themselves 'Ani'-Yun' wiya' - 'Principal People' - the 'Keetoowah' - 'People of Kituhwa' - or Tsalagi from their own name for the Cherokee Nation - migrated to the Southeast from the Great Lakes Region.
Very basic to the Cherokee belief system is the premise that good is rewarded, while evil is punished.  The numbers four and seven are sacred numbers.

The spirits foretold that the monster with white eyes would cross the great eastern water.  The monster would possess evil and terrifying power, and would wreak destruction in its path.  The spirits of the animals and trees began to wither.  Prophecy states that Mother Earth herself would be devastated and her heartbeat would become faint. The monster was said to devour the children of Turtle Island tribe by tribe, with no escape.  If one did survive, its spirit would be dead since it would now be lost and have no connection to its ancestors.  The story tells that one day the Earth would begin to sing a death song due to the severity of the harsh conditions.  When this happens, the children of the people who followed the white-eyed monster to the island would look into their hearts and realize that they faced annihilation at the hands of their fathers.  They would find that the spirits of the children of the tribes had been reborn, waiting to guide the children of the white-eyed monster.  The few keepers of the truth would emerge, becoming strong enough to overcome the power of the white-eyed monster, restoring Mother Earth back to health.  The children of the tribes of Turtle Island would lead the people back to the right way. The races would live in peace, the spirit of the animals and trees would return to safety, and the monster with white eyes would fail to exist.
Other such prophecies are to be found in the Cherokee Legend of the White Snake.

 There was the cycle of the mineral, the rock. There was the cycle of the plant. And now we are in the cycle of the animal coming to the end of that and beginning the cycle of the human being. When we get into the cycle of the human being, the highest and greatest powers that we have will be released to us.
(This is obviously not referring to the typical human, but to those who overcome their animal nature and become spiritual.)

[The Great Spirit] gave each of us a responsibility, and we call that the Guardianship. To the Indian people, the red people, He gave the Guardianship of the Earth. He gave the yellow race of people the Guardianship of the Wind.  He gave the black race of people the Guardianship of the Water.  He gave the white race of people the Guardianship of the Fire.  The Great Spirit gave each of the four races two stone tablets.

"When you see the sun rising in the east, and you see the sign of life reversed and tilted in the east, you will know that the Great Death is to come upon the earth. Now is when the Great Spirit will grab the earth again in His hand and shake it, and this shaking will be worse than the first."
(The sign of life reversed and tilted is the Swastika so this is predicting WWII).

When the Earth sees the fingers of Spearfinger strike Jupiter, when the ages of the Rings and wheels tell it is the ending of the ages of cycles of 5, this will be the sign for the whole earth, for all the earth will see this thing, to wake up from sleep.
(These spear fingers that stuck Jupiter were the comet fragments that hit Jupiter in the 1990s.)

In the year 2004 and 2012 an alignment will take place both on the Cherokee Calendar and in the heavens of the Rattlesnake Constellation both. It is the time of the doublehead serpent stick. It is the time of the Red of Orion and Jupiter against White Blue of Pleiads and Venus. It is the time of the Uku's choosing. It is the time of the Beloved Woman and MYSTERIES OF TIME UNTIME. It is the Time Untime of the THUNDERBOLT and the spirits of Lightning Mountains.

And in the Year 2012 the Cherokee Calendar Ends. And all is reborn.